For François Laruelle “philosophy” is the name for the self-sufficient and self-satisfied thought based on the primacy given to its own transcendental organisation of concepts over and above the real. “Science” is the name for the primacy given to the real. It is to be noted that this is no absolute exclusive opposition, but a question of the asymmetric and unequal composition of real and transcendental determinations in a path of thinking.
Contrary to what some Laruellians may say the criterion of demarcation between science is neither absolute (there is no science without transcendental components) nor one of degree (one cannot maintain that science has “fewer” transcendental components, reducing them to a supposed “minimum”). This “asymmetric and unequal” character is what Laruelle calls “uni-laterality”, its non-opppositional nature, concerning primacy rather than some hypothetical pure state of separation, is what he calls “in-the-last-instance”.